Frequently asked questions

The platform
What is phenotypic discovery, and how is it different from target-based approaches?
It tests compounds for a desired biological outcome directly, without first choosing a molecular target. Read the full explainer →
How is this different from AlphaFold or other structure-based virtual screening tools?
Structure-based methods model binding. Phenotypic screening measures the cell's functional response directly, capturing polypharmacology and context effects that docking does not. See the comparison →
Do I need a known target to use Reflector?
No. Working without a known target is one of the core differences between phenotypic and target-based prediction. See where phenotypic prediction fits →
Data and fit
We have a proprietary assay with around 100 screened compounds and no public equivalent. Can you still generate predictions?
Yes. Our foundation model transfers knowledge across assay types, so a 100-compound screen with a robust readout is enough to fine-tune on. See a case study →
We shelved a program years ago. Is there anything useful you can extract from the archived data?
Often, yes. We can re-score an archived library against new endpoints and surface candidates the original pipeline deprioritized. See a case study →
What counts as a minimum viable dataset for fine-tuning?
As few as 50 small molecules with a quantitative endpoint, more if the assay modality is unusual. Contact us to discuss your data →
Working together
Our med-chem team keeps hitting off-target effects late in lead optimization. Can you help triage before synthesis?
Yes. Phenotypic response is predicted across cell contexts before compounds are committed to synthesis. See a case study →
How long does an engagement take, and what does it cost?
A scoping call, then four weeks from data to prioritized candidates. Pricing is based on outcome rather than time.
Do we need to share our data before deciding to work together?
No. The scoping call assesses fit before any data changes hands.

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